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Pericardial tamponade is an important cause, which typically presents early following penetrating thoracic trauma, but can have a delayed and insi- dious presentation following blunt trauma and when result- ing from numerous medical needs etiologies. This is an exceedingly difficult task since (1) the binding site of the oL4132 receptor is not well characterized, (2) numerous nicotinic pharmacophores likely exist given the diversity of nAChR subtypes, and (3) different allosteric states for any specific receptor subtype may possess different phar- macophores (Karlin, 1993).

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